Use
Sterilization, HTST Treatment, Inactivation
Continuous sterilizers
GMP Continuous Sterilizers: Optimization & Performance for your heat-sensitive fluids and media
Actini Group’s continuous sterilizers are the gold standard for the thermal treatment of critical liquids within the pharmaceutical, biotechnology, cosmetic, and food industries. Utilizing state-of-the-art heat transfer technology, they guarantee reliable sterilization, total control over the sterilization value (F0), and high industrial throughput.
- Steril’Flex: The modular solution for complex and viscous media.
- Steril’One: Compact "Plug & Play" equipment for standard requirements.
- Steril’Rent: Pilot unit rental for your R&D trials and process validations.
Discover our continuous sterilizers
Why choose continuous sterilization (UHT)?
Unlike autoclave (batch) sterilization, the continuous process (Ultra High Temperature) allows for instantaneous heating of the product. This method offers decisive advantages for your production lines:
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Protection of thermolabile molecules: The very short residence time at high temperatures preserves sensitive active ingredients, vitamins, and organoleptic qualities.
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Energy efficiency: Up to 80% energy recovery thanks to our high-performance heat exchangers.
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Constant productivity: An uninterrupted flow from 100 to 20,000 L/h, eliminating downtime between loading cycles.
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Biological safety: Guaranteed maximum sterility for your culture media and nutrient solutions.
Actini Group: Customized & Sustainable Sterilization Solutions
Actini Group offers continuous sterilizers that combine reliability, efficiency, and respect for heat-sensitive products.
Each project begins with a thermal characterization of your product to determine the most suitable sterilization method, followed by pilot trials to optimize parameters and reduce risks. We don’t just sell a machine; we design the ideal thermal path for your fluids.
We then design customized industrial installations, integrating specific tanks or modules as needed, rigorously tested before commissioning. Our teams support installation, operator training, and equipment validation, while offering reactive after-sales service and scalable solutions to guarantee long-term performance and durability.
Technical Specifications
Products
Variable viscosity from 1 to 1,000 cP: Nutrient media (agar, glucose solutions, saline, proteins), Fermentation broth, Active ingredients (peptides, insulin...), Plant extracts, molasses, flavorings...
Treatment Program
Programmable treatment temperature from 90°C to 150°C
Rental - Steril'Rent
Pilot rental available at the Actini site (Evian-les-Bains, France) or at the customer's site
From study to customized industrialization
1. Product Analysis & Characterization
We study the viscosity, stability, and thermal resistance of your fluid. If necessary, physico-chemical analyses are performed on samples to define the design of the exchangers (tubular or plates).
2. Pilot Trials & F0 Validation
With Steril’Rent, test your product under real conditions. This validates the technology, optimizes thermal kinetics, and secures your investment (CAPEX).
3. Industrialization & cGMP Manufacturing
Our facilities are manufactured in France using high-quality stainless steel. We integrate specific options such as DNA removal modules, aseptic storage tanks, or CIP (Cleaning in Place) systems.
4. Installation & Qualification (IQ/OQ/PQ)
Our experts supervise technical installation and team training to ensure rapid operational autonomy. They also assist in drafting and executing qualification protocols (IQ/OQ/PQ) compliant with FDA requirements.
5. Service, Maintenance & Data Integrity
Benefit from reactive after-sales service and our SoBatch supervision system, compliant with 21 CFR Part 11, ensuring total traceability of your production batches. Our maintenance contracts and centralized supervision solutions ensure the longevity and data integrity of your equipment.
Your complex media deserve unique expertise
Whether dealing with cell culture media, nutrient solutions, or sensitive pharmaceuticals, our sterilizers adapt to the specific nature of your fluids. Every piece of equipment is designed to place your product at the heart of the process, guaranteeing total asepsis and protection against thermal degradation.
Thanks to this expertise, our systems allow for both single and multi-product configurations, offering maximum flexibility for your laboratories or industrial production lines.
Modularity and high technological precision
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Aseptic Design: Use of fully aseptic tubular heat exchangers to prevent any risk of contamination.
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Adjusted Thermal Control: Programmable treatment temperatures and holding times (chambrage) to respect the heat sensitivity of each product.
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Energy Efficiency: A combination of tubular and plate technologies to optimize energy recovery on high-capacity units.
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Precision Regulation: A system that eliminates any risk of overheating to preserve the integrity of the treated solutions.
Design focused on safety and compliance
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Full Automation: Secure management and automatic recording of production and cleaning cycles (SIP/CIP) via PLC.
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Guaranteed Repeatability: Perfect recipe management to ensure consistent production quality.
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Total Regulatory Compliance: Equipment meeting cGMP, FDA, and GAMP 5 standards, as well as 21 CFR Part 11 directives for digital traceability.
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Industrial Safety: Design compliant with IEC 61010-1:2010 electrical safety standards and the 2014/68/EU Pressure Equipment Directive (PED).
Discover our range of continuous sterilizers
Models |
Hourly Capacity |
Technology |
Applications |
|---|---|---|---|
| Test Pilot - Steril'Rent | 20 to 500 L/h | Electric heating - Actijoule (single pass) - Aseptic tubular design - Cooling heat exchanger - Pumps (centrifugal and positive displacement) | Product testing • Product characterization • Sterilization validation • Shelf-life testing • Product launches • Small multi-product series • SHORT OR LONG-TERM RENTAL AVAILABLE |
| Industrial Pilot - Steril'One | 500 to 20,000 L/h | Electric or steam heating • 100% tubular or mixed technology (tubular/plate) | Small series production - Contract manufacturing (CMO) - Product launches |
| Production Sterilizer - Steril'Flex | 2,000L to 40,000L | Steam heating - Tubular design for heating and holding - Mixed tubular/plate technology for recovery and cooling | Large-scale industrial production applications |
A complex cGMP sterilization project?
Entrust your cGMP sterilization projects to Actini Group to secure your processes and guarantee the compliance of your facilities.
Our experts design your custom thermal path and validate your parameters prior to industrialization.
